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It's not the stacking, but the batteries used to do it. The RCR123A cells are meant to replace the CR123A primary batteries and are the 3.2V LiFePO4 type of Li-Ion. These are only rated for 1C and are severely overloaded when used to power an atomizer. So, they tend to blow up in your face. This is where stacked batteries get a bad rap. The same thing could happen if you used one of those batteries single.Stacking IMR cells is no more hazardous than running them single. However, with 7.4V nominal, you need higher resistance. A 6.8 Ohm coil would result in a power consumption of about 8 Watts which is actually pretty low. I'd probably use a resistance that gets me around 15 Watts which would be about half that.
We're talking about mechs. For a regulated mod, the output is going to be as set regardless of input voltage. Of course, whether you can use stacked cells or not depends on the mod. If you tried to stack cells in a Pro-Vari, you'd fry the electronics, expensive mistake. If you tried to use a single cell with a home brew mod using a step down regulator, it wouldn't run.With a mech, power consumption is always going to be the square of battery voltage over atomizer resistance regardless of whether that voltage is 3.7V or 7.4V. Coil construction does make a big difference in vaping performance, but power quantifies heat. The heat produced will be in terms of voltage and resistance. That's regardless of whether it's a higher voltage with a higher resistance or a lower voltage with a lower resistance.
No, Vamo is designed to use either stacked or single batteries. You get a little better efficiency with stacked batteries since it bypasses the booster, but a good ICR 18650 cell has a lot more charge capacity than two IMR 18350's. Personally, I'd go with a high quality ICR 18650 battery on the Vamo and only use an IMR 18350 for the single cell short configuration. The reason they give you the option is so you only need to stock one battery size for both the long and short configurations.